The association between cannabis use and “psychotic-like experiences” appeared to be largely influenced by genetic predisposition, according to a cross-sectional study.
Across a sample of twin and non-twin sibling pairs, frequent cannabis users were more likely to report psychotic-like experiences than their relatives who used cannabis less frequently (β=0.08-0.13, P0.001), reported Nicole Karcher, PhD, of Washington University in St. Louis, and colleagues.
Specifically within non-twin relatives, those who used cannabis more frequently were more likely to undergo psychotic-like experiences (β=0.23-0.41, P0.05), they wrote in JAMA Psychiatry.
However, cannabis involvement — frequent or current use; cannabis use disorders — was also tied to greater number of psychotic-like experiences, the authors pointed out.
Genetic factors accounted for 69.2% to 84.1% of the association between frequent, current, and dependent cannabis use and psychotic-like experiences, and this heritability remained significant after adjusting for covariates, although it was reduced. The remainder can likely
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