News on the Green

Male and female cannabis users are affected quite differently by consumption of the same cannabis. Historically scientists have attributed these distinctions to everything from culturally prescribed gender roles to fat tissue distribution and muscle mass. Published in Frontiers in Behavioral Neuroscience’s latest volume, “The Modulating Role of Sex and Anabolic-Androgenic Steroid Hormones in Cannabinoid Sensitivity” reviews data derived from animal studies and concludes that sex differences in cannabis response are both cultural and biological and that sex hormones modulate human cannabinoid sensitivity.

Conducted by University of Cagliari researchers, the study examines the ways in which sex hormones like estradiol (aka estrogen), progesterone and testosterone influence both the formation and action of the human endocannabinoid system, endogenous brain cell networks that communicate using cannabinoids, cannabis’ primary chemical constituent. For example, the number of CB1 cannabinoid receptors

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