Scientists from University of Cagliari and CNR Institute of Neuroscience looked specifically at how cannabinoids affect males and females differently based on the sex hormones testosterone and estrogen.
“Similarly to other drugs of abuse, cannabis use differs remarkably between males and females … indicating a different sensitivity to cannabinoid-induced effects in the two sexes,” the authors reported in the October 26, 2018, issue of Frontiers in Behavorial Neuroscience, a peer-reviewed scientific journal. “Although it remains uncertain which specific biological (i.e., sex) and socio-cultural (i.e., gender) factors affect cannabis use in humans, animal studies strongly suggest the involvement of sex … and anabolic-androgenic steroids (AAS) hormones … as important modulators of cannabinoid sensitivity.”
Past studies have connected the amount of certain sex hormones in our bodies with differences in how the endocannabinoid system functions. For example, in women, high levels of estrogen limit the endocannabinoid system’s ability to react to THC.